This is the Kitty The Sylvester & Tweety Mysteries : Season 5 Episode 1

Granny narrates and is a souvenir volunteer at the city zoo while Sylvester is trying to pursue Tweety who lets a Jack Webb-like detective and animals get in his way. You can see Sylvester's green brain with yellow tentacles that Hector is holding when he does not spit out Tweety.