I'll Take Care of the Majin, Vegeta's Final Desperate Battle! Dragon Ball Kai: Doragon bôru kai : Season 5 Episode 21

Vegeta, willing to put his life on the line, begins his assault on Buu, managing to blast a hole through him. However, Buu manages to regenerate himself and builds up his anger to create a giant explosion, dealing a great amount of damage to Vegeta.